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desvenlafaxine will enhance the degree or influence of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by as much as 50%; no dosage adjustment needed with desvenlafaxine doses 7 consecutive times quickly